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dansiego3

Temecula, CA

Member Since 2016

Followers 228 Following 2585

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A geeky poem i wrote

Jul 7, 2017
5
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Inside

Every one of your cells

Trillions of copies

You have a protein

Named histone h3

Goes by 3.1

Or by 3.3

At the very "beginning"

Of this protein

Are short structural domains

Like artk

Or similar amino acids

These 4 amino acids

In 4 copies

Sit amidst

20 other amino acids

These structures

Are critical for life

To succeed

The arginine = "r"

Is methylated

Into me1

And me2

Sometimes symmetric

Sometimes asymmetric

Several enzymes methylate

And demethylate

While right next door

The threonine = "t"

Or serine, sometimes,

Gets phosphorylated

By other enzymes

Known as kinases

And the phosphate removed

Occasionally

By phosphatases.

The "k" is lysine

And lysine is important

Because it can be acetylated.

And deacetylated.

And methylated once,

Twice, or three times

Me1, me2 or me3

By acetyltransferases

And deacetylases

And methyltransferases

And demethylases

Dozens of enzymes

Constantly change

The chemistry

And structure

Of this protein's

Amino terminus

This code

A complex dance

Of biochemistry and mind

Is read

By other proteins

Which help

Distribute the activities

Coordinating

Machines

Enzymes

To open up your dna

And allow

Your genes

To be

Turned on

Or silenced

Exactly

As the cell

Needs...

Four amino acids

Of the twenty

Allow this to happen

Just by occurring

Next to

Each other

On one or more proteins

Inside your nucleus

Inside your cells

With dna wrapped

Around it

This protein

Histone h3.1

Or 3.3

Combines with itself

And 6 other protein subunits

To form an octamer

2 molecules h2a

2 molecules h2b

2 molecules h3

2 molecules of h4

Positively charged

Fat with lysine

They wrap your dna

Two times around

A protein spool

And save space

In doing so

2 meters

Of dna

Inside each one

Of your little cells

Your littler nuclei

Are fat with code

Both linear

And structural

From dna

From rna

And from the histones

We call this chromatin

I sell chromatin

In many combinations

We all explore

The landscape

Of chromatin

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