summamentis

SUBSTANCE: **CAFFEINE**
TRADE NAMES/SYNONYMS:
1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-;
1H-PURINE-2,6-DIONE,3,7-DIHYDRO-1,3,7-TRIMETHYL-, THEINE;
3,7-DIHYDRO-1,3,7-TRIMETHYL-1H-PURINE-2,6-DIONE;
1,3,7-TRIMETHYL-2,6-DIOXOPURINE; 1,3,7-TRIMETHYLXANTHINE; TRIMETHYLXANTHINE;
7-METHYLTHEOPHYLLINE; METHYLTHEOBROMINE; ALERT-PEP; CAFEINA; CAFFEIN;
CATIPEL; GUARANINE; KOFFEIN; MATEINA; NO-DOZ; REFRESH'N; STIM; THEIN;
C8H10N4O2;
CHEMICAL FAMILY:
Alkaloid
MOLECULAR FORMULA: C8-H10-N4-O2
MOLECULAR WEIGHT: 194.19
CERCLA RATINGS (SCALE 0-3): HEALTH=3 FIRE=1 REACTIVITY=0 PERSISTENCE=1
NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=1 REACTIVITY=0



TRANSPORTATION DATA
U.S. DEPARTMENT OF TRANSPORTATION SHIPPING NAME-ID NUMBER, 49 CFR 172.101:
Poisonous solids, n.o.s.(caffeine)-UN 2811
U.S. DEPARTMENT OF TRANSPORTATION HAZARD CLASS OR DIVISION, 49 CFR 172.101:
6.1 - Poisonous materials
U.S. DEPARTMENT OF TRANSPORTATION PACKING GROUP, 49 CFR 172.101:
PG III
U.S. DEPARTMENT OF TRANSPORTATION LABELING REQUIREMENTS, 49 CFR 172.101
AND SUBPART E:
Keep away from food
U.S. DEPARTMENT OF TRANSPORTATION PACKAGING AUTHORIZATIONS:
EXCEPTIONS: 49 CFR 173.153
NON-BULK PACKAGING: 49 CFR 173.213
BULK PACKAGING: 49 CFR 173.240
U.S. DEPARTMENT OF TRANSPORTATION QUANTITY LIMITATIONS 49 CFR 172.101:
PASSENGER AIRCRAFT OR RAILCAR: 100 kg
CARGO AIRCRAFT ONLY: 200 kg
University of California - MSDS System PAGE 3
06/27/97
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TOXICITY
CAFFEINE:
TOXICITY DATA:
ANHYDROUS: 320 mg/kg oral-child LDLo; 192 mg/kg oral-human LDLo;
14700 ug/kg oral-infant TDLo; 13 mg/kg oral-man TDLo; 96 mg/kg/1 day
intermittent oral-woman TDLo; 1 gm/kg oral-woman LDLo; 192 mg/kg oral-rat
LD50; 127 mg/kg oral-mouse LD50; 224 mg/kg oral-rabbit LD50; 100 mg/kg
oral-cat LDLo; 140 mg/kg oral-dog LD50; 230 mg/kg oral-guinea pig LD50;
230 mg/kg oral-hamster LD50; 170 mg/kg subcutaneous-rat LD50; 242 mg/kg
subcutaneous-mouse LD50; 275 mg/kg subcutaneous-rabbit LDLo; 7 mg/kg
intravenous-human TDLo; 57 mg/kg intravenous-woman LDLo; 68 mg/kg
intravenous-infant TDLo; 105 mg/kg intravenous-rat LD50; 62 mg/kg
intravenous-mouse LD50; 58 mg/kg intravenous-rabbit LD50; 240 mg/kg
intraperitoneal-rat LD50; mutagenic data (RTECS); reproductive effects
data (RTECS); tumorigenic data (RTECS).
MONOHYDRATE: No data available.
CARCINOGEN STATUS: Human Inadequate Evidence, Animal Inadequate Evidence (IARC
Group-3).
ACUTE TOXICITY LEVEL: Toxic by ingestion.
TARGET EFFECTS: Poisoning may affect the central nervous system and heart.
AT INCREASED RISK FROM EXPOSURE: Persons with glaucoma, duodenal ulcers,
liver, cardiovascular, renal or psychological disorders.
ADDITIONAL DATA: May cross the placenta. May be excreted in breast milk.
Alcohol may enhance the toxic effects. Interactions with medications have
been reported.