I'm not involved with homestarrunner -- I went to film school with one of its creators, though, and can't believe how well received what were a bunch of goofy inside-jokes have been. It's a definite favorite of mine and I love that it's now his full-time career.
NedMex was started by a guy who used to be one of my students. He decided he would make a better resturanter than software nerd. Welcome aboard. Love Devotchka, saw them with Cafe Tacuba.
I'm just starting out in comics -- have yet to pay the dues -- but I'm working for Dark Horse's new education dept. on a series of informative stories by kids. My day job is illustration, primarily for Kaplan, Inc. It's not exactly what I want to do -- but I'm paid to draw, so I can't complain.