Yes, actually the first Panty Raid party forced me to go and download a lot of tracks that I wouldn't have normally played. It gave me a new perspective on DJing and a fresh look at what gets people out on the dance floor. It's also nice to change things up for yourself once in a while too. Keep things interesting and challenging.
Oh and as far as using CDs, I'm going to go that route exclusively because they really are tremendously easier to travel with. I'm currently DLing all the tracks that I have on vinyl that I play out regularly and burning them to CD.
It seems we've (by this I mean nearly all of my friends) reached that age range.