Are you just looking for something simillar to the cyberpunk-hot-androids-with-guns segment? or are you looking for more the Insanely-complex-political/philisophical-mindfuck segment?
hmm, a little from column A and a little from column B. I don't mind really although I prefer a more serious and 'realistic' world rather than a comedic and fluffy one.
Thanks for the other suggestions folks, I have actually watched a bit of Appleseed and loved Ex Machina!
Try RD Sennou Chosashitsu (also known as Real Drive) It's currently airing in Japan but you can download some Fansubbed episodes. It's not really cyber punk, but it is interesting sci-fi with very well done animation and an interesting and complex plot.